The Role of Manganese in Human Health

Manganese, an essential trace mineral, plays a pivotal role in maintaining human health and well-being. While its presence in the body may be relatively minute, its impact is substantial. This article delves into the multifaceted functions of manganese, shedding light on its involvement in metabolism, bone health, immune system support, and much more. Drawing on the latest scientific research and expert opinions, we’ll explore the vital role manganese plays in the human body, supporting the claims with relevant sources.

what does manganese do for the body
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Manganese: An Overview

Manganese is a coenzyme that assists many enzymes involved in breaking down carbohydrates, proteins, and cholesterol, as established in studies like [1]. It is a naturally occurring element found in various foods, such as nuts, grains, leafy vegetables, and tea. The Recommended Dietary Allowance (RDA) for manganese, set by the Institute of Medicine, varies by age and gender, with the adult RDA typically around 2.3 milligrams for men and 1.8 milligrams for women [3].

Manganese and Carbohydrate Metabolism

Carbohydrates as Fuel

Carbohydrates serve as the body’s primary source of energy. Digesting and metabolizing these carbohydrates into usable energy requires the assistance of enzymes, many of which rely on manganese as a coenzyme. Notably, manganese plays a crucial role in the enzyme pyruvate carboxylase, which is involved in gluconeogenesis, a process by which the body synthesizes glucose from non-carbohydrate precursors [4]. This is especially important during periods of fasting or low carbohydrate intake when the body needs to produce glucose to fuel various cellular functions.

Moreover, manganese aids enzymes in the tricarboxylic acid (TCA) cycle, a vital metabolic pathway that produces energy through the breakdown of carbohydrates and fats. It participates in the activation of enzymes like malate dehydrogenase and isocitrate dehydrogenase, which are essential for this cycle [5].

Manganese and Lipid Metabolism

Manganese also contributes to lipid metabolism, assisting in the breakdown of fats and cholesterol. Enzymes involved in fatty acid synthesis and lipid metabolism, such as acetyl-CoA carboxylase and fatty acid synthase, require manganese as a cofactor to perform their functions [6]. The role of manganese in cholesterol metabolism is particularly significant, as high cholesterol levels can have adverse effects on cardiovascular health.

Bone Health and Manganese

Manganese and Bone Formation

Manganese is an indispensable element in the process of bone formation and maintenance. The mineral is a coenzyme for enzymes involved in the synthesis of glycosaminoglycans and proteoglycans, which are critical components of cartilage and bone [7]. Additionally, manganese plays a role in the cross-linking of collagen, a protein that provides structural support to bones and connective tissues [8].

Studies have shown that inadequate manganese intake can lead to impaired skeletal development, as it directly affects the quality and strength of bones. In particular, a deficiency in manganese can result in bone malformations, making it essential for growing children and preventing bone-related disorders in adults [9].

Manganese and Osteoporosis

Osteoporosis is a condition characterized by the weakening of bones and an increased risk of fractures. Manganese has been investigated for its potential role in the prevention of osteoporosis. A study published in the “Journal of Bone and Mineral Research” found that higher dietary manganese intake was associated with increased bone mineral density in postmenopausal women, which is a positive indicator of bone health [10]. Although more research is needed, these findings suggest that manganese intake may be a factor in reducing the risk of osteoporosis.

Manganese and Immune System Support

The immune system is our body’s primary defense against infections and diseases. Manganese contributes to immune system support in various ways.

Manganese and Antioxidant Defense

One of the essential roles of manganese in the immune system is its contribution to antioxidant defense. Antioxidants are molecules that neutralize harmful free radicals, preventing them from causing cellular damage. Manganese-dependent enzymes like manganese superoxide dismutase (MnSOD) play a pivotal role in neutralizing superoxide radicals, a harmful type of free radical generated during normal metabolic processes [11].

Wound Healing and Blood Clotting

Manganese works synergistically with vitamin K to support wound healing through blood clotting. Vitamin K is involved in the production of clotting factors, while manganese plays a role in the activation of enzymes responsible for the formation of a fibrin clot, sealing wounds and preventing excessive bleeding [12].

Manganese and Reproductive Health

Manganese is also crucial for maintaining reproductive health. In both males and females, manganese plays a role in fertility. In men, it is involved in sperm production, and in women, it plays a role in the development of the reproductive organs.

Manganese and Male Reproductive Health

Studies have indicated that manganese deficiency can lead to reproductive issues in men. Manganese is a cofactor for the enzyme arginase, which is involved in the metabolism of arginine, an amino acid necessary for sperm production [13]. Inadequate manganese levels may lead to reduced sperm count and impaired sperm motility.

Manganese and Female Reproductive Health

Manganese is also essential for female reproductive health. It is involved in the development and maintenance of the female reproductive organs and the regulation of the menstrual cycle. Research has shown that manganese deficiency can lead to irregular menstruation and impaired fertility in women [14].

Manganese and Neurological Function

Manganese’s role in neurological function is an area of growing interest. While manganese is essential for proper brain function, excessive manganese exposure can have adverse effects on the nervous system. Manganese is required for the synthesis of neurotransmitters like dopamine, norepinephrine, and serotonin, which play key roles in mood regulation and cognitive function [15].

On the other hand, overexposure to manganese, often encountered in industrial settings or through contaminated water sources, has been associated with neurotoxicity, leading to a condition known as manganism. Manganism shares some similarities with Parkinson’s disease, with symptoms including tremors, muscle rigidity, and impaired motor skills. Managing manganese exposure, therefore, is critical to prevent neurological issues [16].

Manganese and Blood Sugar Regulation

Manganese is also linked to blood sugar regulation, primarily through its role in insulin function. Insulin is a hormone produced by the pancreas that regulates blood sugar levels. Manganese is believed to be essential for the proper synthesis and secretion of insulin [17]. Research suggests that manganese deficiency can impair insulin action, potentially leading to glucose intolerance and an increased risk of developing type 2 diabetes [18].

Manganese in Antioxidant Defense

Manganese’s contribution to antioxidant defense extends beyond its role in the immune system. Antioxidants play a crucial role in protecting cells from oxidative stress, which can lead to various diseases, including cancer and cardiovascular conditions.

Manganese superoxide dismutase (MnSOD), a manganese-dependent enzyme, is a powerful antioxidant enzyme found in the mitochondria, the energy-producing organelles in cells. MnSOD helps protect cells from damage caused by free radicals, which are highly reactive molecules that can harm cell membranes, proteins, and DNA [19].

Manganese and Disease Prevention

Manganese’s involvement in various metabolic and physiological processes contributes to disease prevention. Adequate manganese intake has been associated with a reduced risk of certain health conditions.

  • Cardiovascular Health: Manganese has been linked to a lower risk of cardiovascular diseases. Studies suggest that manganese may help reduce the risk of hypertension and improve heart health by preventing oxidative stress, which can lead to blood vessel damage [20].
  • Osteoarthritis: Manganese supplements have shown promise in alleviating the symptoms of osteoarthritis. Osteoarthritis is a degenerative joint disease, and manganese’s role in cartilage formation and maintenance makes it a potential candidate for managing this condition [21].

Manganese Deficiency and Excess

As with most nutrients, the key to reaping manganese’s benefits is balance. Both deficiency and excess of manganese can have detrimental effects on health.

Manganese Deficiency

Manganese deficiency is relatively rare, primarily because the mineral is found in a variety of common foods. However, certain health conditions, such as malabsorption disorders, can lead to insufficient manganese intake. Symptoms of manganese deficiency can include skeletal abnormalities, impaired growth in children, and reproductive issues in both men and women [22].

Manganese Toxicity

On the other end of the spectrum, excessive manganese intake can lead to toxicity and pose serious health risks. Chronic exposure to high levels of manganese can result in manganism, a condition with symptoms similar to Parkinson’s disease, as mentioned earlier [16].

Excessive manganese exposure can occur in industrial settings, such as mining and welding, and can also result from drinking water with high manganese content. Therefore, it is crucial to monitor manganese intake and exposure carefully.

Food Sources of Manganese

A well-balanced diet that includes a variety of foods can help ensure an adequate intake of manganese. Some foods that are good sources of manganese include:

  • Whole grains, such as oats, brown rice, and whole wheat
  • Nuts and seeds, including almonds, pecans, and pumpkin seeds
  • Legumes, like chickpeas and lentils
  • Leafy green vegetables, such as spinach and kale
  • Tea
  • Pineapple
  • Pine nuts
  • Sweet potatoes
  • Avocado
  • Oysters


Manganese is a trace mineral that plays an integral role in various physiological processes in the human body. It acts as a coenzyme for numerous enzymes involved in carbohydrate and lipid metabolism, bone health, immune system support, and more. Its influence on bone formation, immune function, and reproductive health underscores its significance in human well-being.

However, achieving the right balance of manganese intake is crucial, as both deficiency and excess can have adverse effects on health. It is essential to obtain manganese through a well-rounded diet that includes foods rich in this essential mineral. The latest scientific research highlights the multifaceted role of manganese in promoting overall health, making it a mineral worthy of attention in our daily dietary choices. As our understanding of the role of manganese in human health continues to evolve, it becomes increasingly evident that this unassuming trace mineral holds the key to numerous aspects of our well-being.

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